Amos Pines

Born: Israel, 1949
Place of work: Department of Medicine ‘T’, Ichilov Medical Center, Tel-Aviv

Education

1966–1970	BSc in Biology, the Hebrew University, Jerusalem
1967–1974	MD, Hadassa Medical School, Jerusalem
1979–1983	Specialization in Internal Medicine, the Chaim Sheba Medical Center, Tel-Hashomer

Clinical experience

1979–1984	Resident and later on senior physician in Medicine, the Department of Medicine 36, the Sheba Medical Center
1984–1986	Senior physician at the Cardiac Rehabilitation Institute, the Sheba Medical Center
1986–1987	Deputy Head, the Department of Medicine “H”, Wolfson Medical Center, Holon
1987–present	Deputy Head, the Department of Medicine “T”, Ichilov Medical Center, Tel-Aviv; Training Israeli and US medical students
1996–1998	Acting Director, the Homecare Unit, Ichilov Medical Center, Tel-Aviv
1988–present	Director, the Menopause Clinic
1999–present	Director, the Osteoporosis Clinic and Bone Densitometry Unit, Ramat-Marpe Hospital, Ramat-Gan Former Secretary of the Israel Menopause Society; currently Vice President of the Israel Menopause Society; President of the International Menopause Society; Board member of the European Menopause and Andropause Society Former Board Member of the European Menopause Journal; currently Board Member of Maturitas, the European Menopause Journal Editorial Board Member of the journal Climacteric
1992–present	Clinical Associate Professor, the Sackler Faculty of Medicine, Tel-Aviv University

Studies

1. Pines A, Fisman EZ, Levo Y, Averbuch M, Lidor A, Drory Y, Finkelstein A, Hetman-Peri M, Moshkowitz M, Ben-Ari E, Ayalon D: The effects of hormone replacement therapy in normal post-menopausal women: measurement of Doppler-derived parameters of aortic flow. American Journal of Obstetrics & Gynecology 164:806–812, 1991.
2. Fisman EZ, Ben-Ari E, Pines A, Drory Y, Shiner RJ, Motro M, Kellermann JJ: Pronounced reduction of aortic flow velocity and acceleration during heavy isometric exercise in coronary artery disease. American Journal of Cardiology 68:485–491, 1991.
3. Pines A, Fisman EZ, Drory Y, Levo Y, Shemesh J, Ben-Ari E, Ayalon D: Menopause-induced changes in Doppler-derived parameters of aortic flow in healthy women. American Journal of Cardiology 69:1104–1106, 1992.
4. Pines A, Fisman EZ, Shemesh J, Levo Y, Ayalon D, Kellermann JJ, Motro M, Drory Y: Menopauserelated changes in left ventricular function in healty women. Cardiology 80:413–416, 1992. Professor Amos Pines
5. Pines A, Fisman EZ, Ayalon D, Drory Y, Averbuch M, Levo Y: Long-term effects of hormone replacement therapy on Doppler-derived parameters of aortic flow in postmenopausal women. Chest 102:1496–1498, 1992.
6. Pines A, Ironi A, Levo Y, Averbuch M, Limor R, Ayalon D: Thyrotropin, menopause and hormone replacement. Journal of Women’s Health 2:197–200, 1993.
7. Pines A, Fisman EZ, Levo Y, Drory Y, Ben-Ari E, Motro M, Ayalon D: Menopause-induced changes in left ventricular wall thickness. American Journal of Cardiology 72:240–241, 1993.
8. Eckstein N, Pines A, Fisman EZ, Fisch B, Limor R, Vagman I, Barnan R, Ayalon D: The effect of the hypoestrogenic state, induced by gonadotropin releasing hormone agonist, on Doppler-derived parameters of aortic flow. Journal of Clinical Endocrinology and Metabolism 77:910–912, 1993.
9. Pines A, Fisman EZ, Averbuch M, Drory Y, Motro M, Levo Y, Weiss A, Rotmensch HH, Ayalon D: The long term effects of transdermal estradiol on left ventricular function and dimensions. European Menopause Journal 2:22–25, 1995.
10. Pines A, Fisman EZ, Averbuch M, Eckstein N, Drory Y, Bakshi R, Hermeling-Fritz I, Levo Y, Motro M, Ayalon Y: Left ventricular function during short-term trandermal estradiol therapy in postmenopausal women: a double-blind placebo-controlled echocardiographic study. European Menopause Journal 3:53–59, 1996.
11. Pines A, Fisman EZ, Shapira I, Drory Y, Weiss A, Eckstein N, Levo Y, Averbuch M, Motro M, Rotmensch HH, Ayalon D: Exercise echocardiography in postmenopausal hormone users with mild hypertension. American Journal of Cardiology 78:1385–1389, 1996.
12. Shemesh J, Frenkel Y, Leibovitch L, Grossman E, Pines A, Motro M: Does hormone replacement therapy inhibit coronary artery calcifications? Obstetrics & Gynecology 89;989–992, 1997.
13. Lev EI, Pines A, Drory Y, Rotmensch HH, Tenenbaum A, Fisman EZ: Exercise-induced aortic flow parameters in early postmenopausal women and middle-aged men. Journal of Internal Medicine 243:275–280, 1998.
14. Pines A, Fisman EZ, Drory Y, Shapira I, Averbuch M, Eckstein N, Ayalon D: The effects of sublingual estradiol on left ventricular function at rest and exercise in postmenopausal women: an echocardiographic assessment. Menopause 5:79–85, 1998.
15. Pines A, Eckstein N, Dotan I, Ayalon D, Varon D, Barnea O, Shavit G: Effect of estradiol on rat ileum. General Pharmacology 31:735–736, 1998.
16. Averbuch M, Ayalon D, Eckstein N, Dotan I, Shapira I, Levo Y, Pines A: Hormone replacement and simvastatin in the therapy of hypercholesterolemic postmenopausal women. Journal of Medicine
29:343–350, 1998
17. Pines A, Dotan I, Tabori U, Villa Y, Mijatovic V, Levo Y, Ayalon D: L-thyroxine prevents the bone conserving effect of HRT in postmenopausal women with subclinical hypothyroidism. Gynecological Endocrinology 13:196–201, 1999.
18. Pines A, Weiss A, Eckstein N, Nadler E, Barnea O, Ayalon D, Shavit G: The effects of 17b-estradiol on ectopic rhythm in human atrial strips. Maturitas 33:171–173, 1999.
19. Fisman EZ, Tenenbaum A, Shapira I, Motro M, Pines A: Lack of effects of transdermal estradiol on diastolic function: a randomized placebo-controlled double-blind short-term trial. Climacteric 2: 174–180, 1999.
20. Pines A, Katchman H, Villa Y, Mijatovic V, Dotan I, Levo Y, Ayalon D: The effect of various hormonal preparations and calcium supplementation on bone mass in early menopause. Is there a predictive value for the initial bone density and body weight? Journal of Internal Medicine 2:174–180, 1999.
21. Fisman EZ, Tenenbaum A, Shapira I, Motro M, Pines A: The acute effects of sublingual estradiol on left ventricular diastolic function in normotensive and hypertensive postmenopausal women. Maturitas 33:145–152, 1999.
22. Tenenbaum A, Fisman EZ, Pines A, Shemesh J, Shapira I, Adler Y, Frenkel Y, Boyko V, Motro M: Gender paradox in cardiac calcium deposits in middle-aged and elderly patients: mitral annular and coronary calcifications interrelationship. Maturitas 35:35–42, 2000.
23. Lomeranz J, Becker D, Eyal N, Pines A, Mester R: Attitudes towards hormone replacement therapy among middle-aged women and men. European Journal of Obstetrics, Gynecology & Reproductive
Biology 93;199–203, 2000.
24. Pines A, Frenkel Y, Fisman EZ, Wolf Y, Lusky A, Ayalon D: The effect of oophorectomy and estrogen replacement on Doppler derived parameters of aortic flow. Maturitas 37:125–128, 2000
25. Pines A, Frenkel Y, Fisman EZ, Lusky A, Ayalon D, Wolf Y: The effect of oophorectomy and estrogen replacement on Doppler derived parameters of aortic flow. Maturitas 37:125–128, 2000
26. Cardiovascular disease and HRT. Position Paper of the International Menopause Society. Climacteric 3:233–241, 2000
27. Becker D, Lomeranz J, Pines A, Shmotkin D, Eyal N, Ben-Amitai G, Mester R: Psychological distress around menopause. Psychosomatics 2001;42:252–257.
28. Pines A, Frenkel Y, Mijatovic V, Margalioth EJ, Dhapira I: The impact of hormonal therapy for infertility on the age of menopause. Maturitas 2002;41:283–287
29. Vogelvang TE, Mijatovic V, Kamp O, Netelenbos JC, Neele SJ, Pines A, Kenemans P, van Der Mooren MJ. Neither long-term treatment with raloxifene nor hormone replacement therapy modulate cardiac function in healthy postmenopausal women: Two randomized, placebo-controlled, 2-year studies. Am J Obstet Gynecol 2002;186:729–736.
30. Pines A, Eckstein N, Kopernik G, Ayalon D, Comaneshter D, Frenkel Y: Month 3 and Month 6 measurements of bone mineral density predict the annual outcome in postmenopausal women with osteoporosis in whom alendronate was added to long-term HRT. Maturitas 2003;44:287–292.
31. Pines A: Lessons from the Women’s Health Initiative (WHI). Harefuah 2003;142:163–165 (Hebrew)

Reviews

1. Ayalon D, Pines A: Cardiovascular disease and hormone replacement therapy. Israel Journal of Medical Sciences 29:660–663, 1993.
2. Mijatovic V, Pines A: Menopause-induced changes in cardiovascular functions and HRT. Europe an Menopause Journal 1:4–9, 1995.
3. van der Mooren MJ, Mijatovic V, Pines A: The cardiovascular risk profile: influence of menopausal status and postmenopausal HRT. Gynecology Forum 1:12–17, 1996.
4. Cardio-vascular risk and the menopause: European Consensus. Participants: Vessey M, Stampfer M, Breart G, Godsland I, Pines A, Samsioe G, Sullivan J. Menopause Review 1:14–23, 1996.
5. European consensus development conference on menopause. Cardiovascular disease and menopause. Participants: Vessey M, Stampfer M, Breart G, Godsland I, Pines A, Samsioe G, Sullivan J. Human Reproduction 11:975–979, 1996.
6. Mijatovic V, Pines A, Stehouwer CDA, van der Mooren MJ, Kenemans P: The effects of estrogens on vessel wall and cardiac function, hemostasis and homocysteine metabolism. in: European position paper on hormone replacement therapy and the menopause. European Menopause Journal 3: 209–218, 1996.
7. Pines A, Mijatovic V, van der Mooren MJ, Kenemans P: Hormone replacement therapy and cardioprotection: basic concepts and clinical considerations. European Journal of Obstetrics & Gynecology and Reproductive Biology 71:193–197, 1997.
8. Pines A, Mijatovic V, van der Mooren MJ: Hormone replacement therapy and cardioprotection in the elderly. Journal of the Royal Society of Medicine 91:475–478, 1998
9. Stevenson J, Samsioe G, Pines A, Huber J, Netelenbos C, de Roo G, Sitruk-Ware R, Barensten R, Palacios S, Koninckx PR: Critical comments on the HERS study (Editorial). Maturitas 31:77–87, 1998.
10. Pines A: Management problems. BRCA mutation, prophylactic oophorectomy and HRT. Climacteric 1:309–310, 1998
11. Pines A, Averbuch M, Fisman EZ, Rosano GMC: The acute effects of sublingual 17β-estradiol on the cardiovascular system. Maturitas 33:81–85, 1999
12. Mijatovic V, Pines A: The first clinical synthesis conference on hormone replacement therapy: new perspectives for HRT? Maturitas 33:87–92, 1999
13. Pines A: The Nurses’ Health Study: unresolved issues after 20-years follow-up. Maturitas 38: 231–233, 2001
14. Pines A, Fisman EZ: Hypertension in menopausal women – a special case for special treatment? Gynecological Endocrinology 2001
15. Pines A: AHA statement on HRT and cardiovascular disease: the tone makes the music. Maturitas 40:9–10, 2001
16. Pines A, Bornstein NM, Shapira I: Menopause and ischaemic stroke: basic, clinical and epidemiological considerations. The role of hormone replacement. Human Reproduction Update 8:161–168, 2002
17. Pines A: Hormone therapy and the cardiovascular system. Maturitas 2002
18. Fisman EZ, Tenenbaum A, Pines A: Systemic hypertension in postmenopausal women: a clinical approach. Current Hypertension Reports 4:464–470, 2002
19. Pines A: Critical comment. HERS and WHI in the right perspective. Maturitas 44:17–18, 2003
20. Pines A: Critical comment. The Million Women Study: what is missing? Maturitas 46:103–104, 2003

Chapters in books

1. Pines A: Cardiac hemodynamics, the menopause, and hormone replacement therapy. In: Progress in the Management of Menopause. Wren BG (ed.). Parthenon Publishing Group Inc., New York, 1997, pp 328–331
2. Pines A: Alterations in cardiac hemodynamics associated with menopause and HRT. In: Menopause and the Heart. Neves e Castro M, Birkhauser M, Clarkson TB, Collins P (eds.). Parthenon Publishing, London 1999, pp 35–37.
3. Pines A: The cardioprotective effect of estrogens in the elderly population. In: New technologies for gynecologic and obstetric investigation. Genazzani AR, Artini PG (eds.). CIC Edizione Internazionale, Rome 1999, pp 261–264.
4. Pines A: Oestrogens and the cardiovascular system in the over 60’s. In: The management of menopause. Studd J, (ed.). Parthenon Publishing Group, Lancs UK, 1999, pp 317–323.
5. Pines A: The Madam Program: A study program exclusively in postmenopausal women. In: The therapeutic challenge in postmenopausal hypertension. Pines A, Schmidt S, Zanchetti A (eds.). Walter de Gruyter, Berlin, 2000, pp 25–32.
6. Pines A: Phytoestrogen and cardiovascular risk. In: The menopause at the Millennium. Aso T, Yanaihara T, Fujimoto S. (eds.). Parthenon Publishing Group, Lancs UK, 2000, pp 337–340.
7. Pines A: Hormone replacement and the primary and secondary prevention of cardiovascular disease. In: Sex hormone replacement therapy. Burger H (ed.). Kluwer Academic Publishers, Norwell, USA, 2000, pp 1–10.