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The Women on the Move Through Activity and Nutrition (WOMAN) study, a 5-year randomized clinical trial, was designed to evaluate whether a non-pharmacological lifestyle intervention, focused on weight loss through dietary and physical activity changes, would reduce the measures of subclinical atherosclerosis among postmenopausal women aged 52–62 years. Data were collected at baseline and at month 48. Pettee and colleagues [1] have recently reported data from the WOMAN study assessing changes in leisure-time physical activity (LTPA) and body composition vis-a-vis concomitant changes in 400-m walk time. At baseline, participants ([i]n[/i] = 508) were randomized to the lifestyle intervention or health education group. The lifestyle intervention focused on weight (7–10%) and waist circumference reduction through healthy lifestyle behavior change. Change in walk time over 48 months was the primary outcome. Secondary measures included change in LTPA and body composition parameters including body weight, body mass index, waist circumference, and dual-energy X-ray absorptiometry-derived fat and lean mass. 

Increased LTPA and reductions in body weight, body mass index, waist circumference, and fat mass were associated with shorter (faster) walk time at month 48 compared to baseline. LTPA was not significantly related to walk time in the health education group. The authors of this study concluded that increased LTPA and weight loss resulted in improved physical function, as measured by the 400-m walk, in a group of overweight, postmenopausal women and that their findings support the use of the 400-m walk to evaluate progress in physical activity or weight loss programs [1].


  • Camil Castelo-Branco
    Ob Gyn Senior Consultant, Hospital Clínic Barcelona, and Full Professor, University of Barcelona, Spain


  1. . Pettee Gabriel KK, Conroy MB, Schmid KK, et al. The impact of weight and fat mass loss and increased physical activity on physical function in overweight, postmenopausal women: results from the Women on the Move Through Activity and Nutrition study. Menopause 2011;18:759-65.
  2. Simonsick EM, Montgomery PS, Newman AB, Bauer DC, Harris T. Measuring fitness in healthy older adults: the Health ABC Long Distance Corridor Walk. J Am Geriatr Soc 2001;49:1544-8.
  3. Pettee KK, Larouere BM, Kriska AM, et al. Associations among walking performance, physical activity, and subclinical cardiovascular disease. Prev Cardiol 2007;10:134-40.
  4. Pettee Gabriel KK, Rankin RL, Lee CD, Charlton ME, Swan PD, Ainsworth BE. Test-retest reliability and validity of the 400 meter walk test in healthy, middle-aged women. J Phys Act Health 2010;7:649-57.
  5. Aragao F, Abrantes C, Gabriel RE, et al. Effects of body composition and menopause characteristics on maximal oxygen uptake of postmenopausal women. Menopause 2011 July 11. Epub ahead of print.
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