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Villalon and colleagues report a study of the effect of weight loss and weight regain on bone mineral density (BMD) in postmenopausal overweight or obese women [1]. They measured BMD and body composition by dual-energy X-ray absorptiometry, biochemical markers of bone formation and resorption, and aerobic power by spirometry (VO[-]2[/-] peak). They found that weight loss over a 6-month period results in significant loss of bone from the lumbar spine and hip. Subsequent weight regain over a 12-month period did not produce any increase in BMD. They conclude that weight maintenance and fitness may be a better strategy than weight reduction for bone and metabolic health.

Author(s)

  • John Stevenson
    National Heart & Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK

Citations

  1. Villalon KL, Gozansky WS, Van Pelt RE, et al. A losing battle: weight regain does not restore weight loss-induced bone loss in postmenopausal women. Obesity 2011; Aug 18. Epub ahead of print
    http://www.ncbi.nlm.nih.gov/pubmed/21852813
  2. Stevenson JC, Banks LM, Spinks TJ, et al. Regional and total skeletal measurements in the early postmenopause. J Clin Invest 1987;80:258-62
    http://www.ncbi.nlm.nih.gov/pubmed/3597775
  3. Yoo HJ, Park MS, Yang SJ, et al. The differential relationship between fat mass and bone mineral density by gender and menopausal status. J Bone Miner Metab 2011; Jun 7. Epub ahead of print
    http://www.ncbi.nlm.nih.gov/pubmed/21644057
  4. El Hage R, Jacob C, Moussa E, Baddoura R. Relative importance of lean mass and fat mass on bone mineral density in a group of Lebanese postmenopausal women. J Clin Densitom 2011;14:326-31
    http://www.ncbi.nlm.nih.gov/pubmed/21600821
  5. Saarelainen J, Honkanen R, Tupperainen M, Jurvelin JS, Niskanen L. Body fat distribution is associated with lumbar spine bone density independently of body weight in postmenopausal women. Maturitas 2011;69:86-90
    http://www.ncbi.nlm.nih.gov/pubmed/21388758
  6. Reid IR. Relationships between fat and bone. Osteoporosis Int 2008;19:595-606
    http://www.ncbi.nlm.nih.gov/pubmed/17965817
  7. Van Pelt RE, Evans EM, Schechtman KB, Ehsani AA, Kohrt WM. Contributions of total and regional fat mass to risk of cardiovascular disease in older women. Am J Physiol Endocrinol Metab 2002;282:E1023-8
    http://www.ncbi.nlm.nih.gov/pubmed/11934666
  8. Krebs EE, Taylor BC, Cauley JA, Stone KL, Bowman PJ, Ensrud KE. Measures of adiposity and risk of breast cancer in older postmenopausal women. J Am Geriatr Soc 2006;54:63-9
    http://www.ncbi.nlm.nih.gov/pubmed/16420199
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