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Villalon and colleagues report a study of the effect of weight loss and weight regain on bone mineral density (BMD) in postmenopausal overweight or obese women [1]. They measured BMD and body composition by dual-energy X-ray absorptiometry, biochemical markers of bone formation and resorption, and aerobic power by spirometry (VO[-]2[/-] peak). They found that weight loss over a 6-month period results in significant loss of bone from the lumbar spine and hip. Subsequent weight regain over a 12-month period did not produce any increase in BMD. They conclude that weight maintenance and fitness may be a better strategy than weight reduction for bone and metabolic health.


  • John Stevenson
    National Heart & Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK


  1. Villalon KL, Gozansky WS, Van Pelt RE, et al. A losing battle: weight regain does not restore weight loss-induced bone loss in postmenopausal women. Obesity 2011; Aug 18. Epub ahead of print
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