The California Teachers Study is a prospective cohort study initiated in 1995–1996 using mailed, self-administered questionnaires. This recently published sub-study compared mortality in 9,785 participants who had a surgical menopause and 32,219 who had a natural menopause . All-cause, cardiovascular and cancer mortality rates were obtained from three Californian data banks and compared to menopausal hormone therapy (HT) use.
Among participants with bilateral oophorectomy aged < 45 years at menopause, relative risks (95% confidence interval) for death were 0.86 (0.74–1.00), 0.85 (0.66–1.11) and 0.91 (0.67–1.23) for all-cause, cardiovascular and cancer mortality, respectively. For those over age 45, the corresponding data were 0.87 (0.80–0.94), 0.83 (0.71–0.96) and 0.84 (0.72–0.98). The association between bilateral oophorectomy and mortality did not differ by baseline status of hormone use. The authors concluded that surgical menopause due to bilateral oophorectomy vs. natural menopause does not increase all-cause, cardiovascular or cancer mortality.
Alastair and Alice MacLennan
The Discipline of Obstetrics & Gynaecology, The University of Adelaide, South Australia
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