Clinical guidelines recommend the routine use of calcium and vitamin D supplementation for the prevention of fractures, especially at old age. Recent publications highlight the strong debate which has erupted in the past 5 years on the safety profile and efficacy of this treatment. I will try to put things in order for those who were not able to follow the situation more closely. In one review, Dr Weaver explains the problem : ‘Recently, calcium supplementation has been linked to both increased and decreased cardiovascular disease risk, creating considerable uncertainty. Moreover, recent reports have shed uncertainty over the effectiveness of calcium supplements to reduce risk of fracture.’ In another review, Dr Reid took this issue further and summarized his view as follows : ‘… findings suggest that calcium supplements have little role to play in the modern therapeutics of osteoporosis …”. So what actually is going on? Are we heading for another revolution in clinical practice? What ignited the fire?
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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