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Wang and colleagues have carried out a cross-sectional study from a 22-site population-based study known as SPECT-China (the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors) [1]. Among other parameters, the authors measured quartiles of serum FSH in a postmenopausal population (average age 63 years) and related this to a calculated 10-year risk of atherosclerotic cardiovascular disease (ASCVD). The increase in FSH levels was inversely correlated with the ASCVD risk, decreasing from 4.9% to 3.3% for higher FSH levels. These associations seemed to remain after adjustments for obesity, diabetes and other metabolic parameters, although body mass index (BMI) and waist circumference showed the strongest associations. The authors concluded that a low FSH might be a risk factor or biomarker for cardiovascular disease in postmenopausal women.

Author(s)

  • Rogerio A. Lobo
    Department of Obstetrics & Gynecology, Columbia Presbyterian Medical Center, New York, NY, USA

Citations

  1. Wang N, Shao H, Chen Y, et al. Follicle-stimulating hormone, its association with cardiometabolic risk factors, and 10-year risk of cardiovascular disease in postmenopausal women. J Am Heart Assoc 2017;6; pii: e005918
    http://www.ncbi.nlm.nih.gov/pubmed/28855169
  2. Randolph JF Jr, Zheng H, Sowers MR, et al. Change in follicle-stimulating hormone and estradiol levels across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab 2011;96:746-54
    http://www.ncbi.nlm.nih.gov/pubmed/21159842
  3. Wang N, Li Q, Han B, et al. Follicle stimulating hormone is associated with non-alcoholic fatty liver disease in Chinese women over 55 years old. J Gastroenterol Hepatol 2016;31:1196-202
    http://www.ncbi.nlm.nih.gov/pubmed/26678239
  4. Wang N, Kuang L, Han B, et al. Follicle stimulating hormone associates with prediabetes and diabetes in postmenopausal women. Acta Diabetol 2016;53:227-36
    http://www.ncbi.nlm.nih.gov/pubmed/25959422
  5. Bertone-Johnson ER, Virtanen JK, Niskanen L, et al. Association of follicle stimulating hormone levels and risk of type 2 diabetes in older postmenopausal women. Menopause 2017;24:796-802
    http://www.ncbi.nlm.nih.gov/pubmed/28141661
  6. Schmidt J, Brannstrom M, Landin-Wilhelmsen K, Dahlgren E. Reproductive hormone levels and anthropometry in postmenopausal women with polycystic ovary syndrome (PCOS): a 21-year follow-up study of women diagnosed with PCOS around 50 years ago and their age-matched controls. J Clin Endocrinol Metab 2011;96:2178-85
    http://www.ncbi.nlm.nih.gov/pubmed/21508129
  7. Song Y, Wang ES, Xing LL, et al. Follicle stimulating hormone induces postmenopausal dyslipidemia through inhibiting hepatic cholesterol metabolism. J Clin Endocrinol Metab 2016;101:254-63
    http://www.ncbi.nlm.nih.gov/pubmed/26583582
  8. Liu XM, Chan HC, Ding GL, et al. FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca (2+)/CREB pathway. Aging Cell 2015;14:409-20
    http://www.ncbi.nlm.nih.gov/pubmed/25754247
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