Recently, contradictory reports were published concerning the association between the serum concentration of irisin and the physical activity level and fitness status in healthy humans. Irisin is a newly identified myokine that induces the ‘browning’ of white adipose tissue (WAT). Buscemi and colleagues studied a cohort of 858 healthy individuals in Palermo, Sicily, as a part of the ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study, and found a significant positive correlation between serum irisin concentration and habitual physical activity [1]. However, Binianinov and colleagues showed that serum irisin concentration was not related to any measures of short-term physical activity, habitual physical activity, or physical fitness in a cross-sectional analysis of 300 healthy humans who had participated in the Karlsruhe Metabolomics and Nutrition (KarMeN) study in Germany [2].
Author(s)
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Masakazu Terauchi
Department of Women’s Health, Tokyo Medical and Dental University, Tokyo, Japan
Citations
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Buscemi S, Corleo D, Vasto S, et al. Factors associated with circulating concentrations of irisin in the general population cohort of the ABCD study. Int J Obes (Lond) 2017;42:398-404
http://www.ncbi.nlm.nih.gov/pubmed/29027533 -
Biniaminov N, Bandt S, Roth A, Haertel S, Neumann R, Bub A. Irisin, physical activity and fitness status in healthy humans: no association under resting conditions in a cross-sectional study. PLoS One 2018; 13:e0189254
http://www.ncbi.nlm.nih.gov/pubmed/29381744 -
Boström P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481:463-8
http://www.ncbi.nlm.nih.gov/pubmed/22237023 -
Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine 2018;59:260-74
http://www.ncbi.nlm.nih.gov/pubmed/29170905 -
Lidell ME, Betz MJ, Enerbäck S. Brown adipose tissue and its therapeutic potential. J Intern Med 2014;276:364-77
http://www.ncbi.nlm.nih.gov/pubmed/24717051
