Villalon and colleagues report a study of the effect of weight loss and weight regain on bone mineral density (BMD) in postmenopausal overweight or obese women [1]. They measured BMD and body composition by dual-energy X-ray absorptiometry, biochemical markers of bone formation and resorption, and aerobic power by spirometry (VO[-]2[/-] peak). They found that weight loss over a 6-month period results in significant loss of bone from the lumbar spine and hip. Subsequent weight regain over a 12-month period did not produce any increase in BMD. They conclude that weight maintenance and fitness may be a better strategy than weight reduction for bone and metabolic health.
Author(s)
-
John Stevenson
National Heart & Lung Institute, Imperial College London, Royal Brompton Hospital, London, UK
Citations
-
Villalon KL, Gozansky WS, Van Pelt RE, et al. A losing battle: weight regain does not restore weight loss-induced bone loss in postmenopausal women. Obesity 2011; Aug 18. Epub ahead of print
http://www.ncbi.nlm.nih.gov/pubmed/21852813 -
Stevenson JC, Banks LM, Spinks TJ, et al. Regional and total skeletal measurements in the early postmenopause. J Clin Invest 1987;80:258-62
http://www.ncbi.nlm.nih.gov/pubmed/3597775 -
Yoo HJ, Park MS, Yang SJ, et al. The differential relationship between fat mass and bone mineral density by gender and menopausal status. J Bone Miner Metab 2011; Jun 7. Epub ahead of print
http://www.ncbi.nlm.nih.gov/pubmed/21644057 -
El Hage R, Jacob C, Moussa E, Baddoura R. Relative importance of lean mass and fat mass on bone mineral density in a group of Lebanese postmenopausal women. J Clin Densitom 2011;14:326-31
http://www.ncbi.nlm.nih.gov/pubmed/21600821 -
Saarelainen J, Honkanen R, Tupperainen M, Jurvelin JS, Niskanen L. Body fat distribution is associated with lumbar spine bone density independently of body weight in postmenopausal women. Maturitas 2011;69:86-90
http://www.ncbi.nlm.nih.gov/pubmed/21388758 -
Reid IR. Relationships between fat and bone. Osteoporosis Int 2008;19:595-606
http://www.ncbi.nlm.nih.gov/pubmed/17965817 -
Van Pelt RE, Evans EM, Schechtman KB, Ehsani AA, Kohrt WM. Contributions of total and regional fat mass to risk of cardiovascular disease in older women. Am J Physiol Endocrinol Metab 2002;282:E1023-8
http://www.ncbi.nlm.nih.gov/pubmed/11934666 -
Krebs EE, Taylor BC, Cauley JA, Stone KL, Bowman PJ, Ensrud KE. Measures of adiposity and risk of breast cancer in older postmenopausal women. J Am Geriatr Soc 2006;54:63-9
http://www.ncbi.nlm.nih.gov/pubmed/16420199
