Skip to content

The incidence of colorectal cancer has been reported to be lower in Asians than in Caucasians, even though rapid increases in Asian countries, particularly in Japan, have been noticed [1,2]. Higher soy food consumption by Asians than by Caucasians has been thought to be one of the possible reasons for the difference. A recently published prospective cohort study [3] evaluated the relationship between soy food intake and colorectal cancer risk in women in Shanghai, China. The study examined 68,412 women 40–70 years of age by assessing their usual soy food intake at baseline (1977–2000) and again at follow-up (2000–2002) through in-person interview with a validated questionnaire. During a mean follow-up of 6.4 years, 321 colorectal cancer cases were identified. The results showed that total soy intake was inversely associated with colorectal cancer risk. Each 5-g/day increase in intake of soy foods was associated with 8% reduction in risk (95% confidence interval (CI) 3–14%). Women in the highest tertile of intake had a risk of 0.67 (95% CI 0.49–0.90) compared with those in the lowest tertile (p for trend = 0.008). This inverse association was primarily confined to postmenopausal women. The authors concluded that consumption of soy foods may reduce the risk of colorectal cancer in postmenopausal women.

Author(s)

  • Ko-En Huang
    Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan

Citations

  1. International Agency for Research on Cancer. Cancer incidence in five continents. Lyon, France: IARC, 2003.
  2. Potter JD, Slattery ML, Bostick RM, Gapstur SM. Colon cancer: a review of the epidemiology. Epidemiol Rev 1993;15:499-545.
    http://www.ncbi.nlm.nih.gov/pubmed/8174669
  3. Yang G, Shu XO, Li H, et al. Prospective cohort study of soy food intake and colorectal cancer risk in women. Am J Clin Nutr 2009;89:577-83. Published February, 2009.
    http://www.ncbi.nlm.nih.gov/pubmed/19073792
  4. Lechner D, Kallay E, Cross HS. Phytoestrogen and colorectal cancer prevention. Vitam Horm 2005;70:169-98.
    http://www.ncbi.nlm.nih.gov/pubmed/15727805
  5. Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogen with estrogen recptor beta. Endocrinology 1998;139:4252-63.
    http://www.ncbi.nlm.nih.gov/pubmed/9751507
  6. Nussler NC, Reinbacher K, Shanny N, et al. Sex-specific differences in the expression levels of estrogen receptor subgroups in colorectal cancer. Gend Med 2008;5:209-17.
    http://www.ncbi.nlm.nih.gov/pubmed/18727987
  7. Hwang CS, Kwak HS, Lim HJ, et al. Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration. J Steroid Biochem Mol Biol 2006;101:246-53.
    http://www.ncbi.nlm.nih.gov/pubmed/16965913
  8. Akhter M, Inoue M, Kurahashi N, et al. Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study. Cancer Epidemiol Biomarkers Prev 2008;17:2128-35.
    http://www.ncbi.nlm.nih.gov/pubmed/18708407
International Menopause Society

Install International Menopause Society - DEV

Install this application on your home screen for quick and easy access when you’re on the go.

Just tap then “Add to Home Screen”

DBS Check Online Certified