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In a recently published study, Jeon and colleagues report on a retrospective analysis of coronary-artery calcium scores in 436 postmenopausal women who underwent computed tomography (CT) scanning in the hospital’s Health Promotion Center [1]. Serum estradiol, lipids and bone mineral densities were also obtained. In women not receiving hormonal therapy, the women were divided into those with serum estradiol levels < 20 pg/ml and those with estradiol levels ≥ 20 pg/ml; the women were also divided into those with coronary artery calcium scores < 100 and those with scores ≥ 100. Women with lower estradiol levels (< 20 pg/ml) had significantly higher calcium scores (p < 0.05). After adjusting for multiple variables by weighted logistic regression, women with higher estradiol levels had a reduced chance of having a higher coronary calcium score (adjusted odds ratio 0.25; 95% confidence interval 0.07–0.86; p = 0.03).


  • Roger Lobo
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, USA


  1. Jeon G-H, Kim,SH, Yun S-C, Chae HD, Kim C-H, Kang BM. Association between serum estradiol level and coronary artery calcification in postmenopausal women. Menopause 2010; May 26. Epub ahead of print.
  2. Manson JE, Allison MA, Rossouw JE, et al. Estrogen therapy and coronary-artery calcification. N Engl J Med 2007;356:2591-602.
  3. Barrett-Connor E, Laughlin GA. Hormonal therapy and coronary calcification in asymptomatic postmenopausal women: the RanchoBernardo Study. Menopause 2005;12:40-8.
  4. Miller VM, Black DM, Brinton EA, et al. Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). J Cardiovasc Trans Res 2009;2:228-39.
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