Ikegami and colleagues  have recently reported that a direct association may exist between insufficiency of 25-hydroxyvitamin D [25(OH)D], bone turnover markers and prior vertebral fractures, independent of parathyroid hormone (PTH) activity. In 330 postmenopausal Japanese women with osteoporosis and normal PTH levels who had never been treated for osteoporosis, serum 25(OH)D levels, bone formation and resorption markers and presence of prior vertebral fractures were analyzed. In subjects with low 25(OH)D levels but normal calcium metabolism and PTH levels, an association was found with low serum osteocalcin/bone alkaline phosphatase (OC/BAP) ratio, low serum inorganic phosphorus levels and presence of prior vertebral fractures. This study revealed that vitamin D may have a direct effect on bone turnover and that 25(OH)D insufficiency is related to higher than normal prevalence of vertebral fractures.
Teodora Beljic Zivkovic
Faculty of Medicine, University of Belgrade, Zvezdara University Medical Center, Belgrade, Serbia
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