Following the publication within the last year of two papers by Bolland and colleagues in the [i]BMJ[/i] [1,2] regarding the relationship between calcium and vitamin D supplements and heart disease, there still seems to be confusion among practitioners despite vigorous discussion and uncertainty regarding the validity of the results. In April 2011, Bolland and colleagues published a meta-analysis that comprised a re-analysis of Women’s Health Initiative Calcium and Vitamin D Study (WHI CaD Study) limited access dataset with eight other studies . There are three components to the paper, a re-analysis of the WHI CaD study, a new meta-analysis of the previous trials of calcium and vitamin D, and an update of the previous analysis published in 2010 . A total of 36,282 women took part in the WHI CaD Study and were followed for 7 years; the main outcome measures were cardiovascular events (myocardial infarction, coronary revascularization, death from coronary heart disease and stroke). The meta-analysis discussed two recent systematic reviews which identified trials of co-administered calcium and vitamin D [3,4], which were brought up-to-date with as much relevant data as could be identified by the authors.
The risk of having an myocardial infarction was slightly increased in women not already using calcium and vitamin D at the start of the study, who were randomized to it in the WHI study (hazard ratio (HR) 1.22; 95% confidence interval (CI) 1.00–1.50; [i]p[/i] = 0.054). However, all-cause mortality was not increased in this group (HR 0.99; 95% CI 0.86–1.14; [i]p[/i] = 0.89). Interestingly, women who were taking calcium supplements at baseline and who were assigned to calcium and vitamin D had a lower all-cause mortality when compared to those assigned to placebo (HR 0.84; 95% CI 0.73–0.97). The authors found a moderate increase in cardiovascular events with calcium and vitamin D usage and concluded that a reassessment of the role of calcium supplements in osteoporosis management is warranted – but is it?
Mary Ann Lumsden
Consultant Gynecologist, Head of Reproductive & Maternal Medicine, University of Glasgow, UK
Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Womens Health Initiative limited access data-set and meta-analysis. BMJ 2011;342:d2040.
Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010;341:c3691.
Hsia J, Heiss G, Ren H, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation 2007;115:846-54.
Chung M, Balf EM, Brendel M, et al. Vitamin D and calcium: A Systematic Review of Health Outcomes. Evidence Report No 183. No 09-E015. Rockville, MD: Agency for Healthcare Research and Quality, 2009.
Drug Safety Update Oct 2011 vol 5, issue 3:H1.