A recent review  was intriguing, since it brought again to our attention the search for a desired molecule which should have optimal dual characteristics: inducing estrogen-like effects on menopause-related symptoms on the one hand, but avoiding the potentially serious adverse effects of postmenopausal hormone therapy on the other hand. Here is an Abstract of this review:
Vulvovaginal atrophy (VVA) in postmenopausal breast cancer patients has a significant impact on quality of life. While the etiology of VVA is primarily related to low estrogen levels seen in menopause, women with breast cancer have an added risk of VVA induced by a combination of chemotherapy, hormonal therapy, and menopause. Ospemifene is a new, non-hormonal selective estrogen receptor modulator (SERM) triphenylethylene derivative that is effective in treating VVA in postmenopausal women. Although other SERMs have antagonistic effects on the vagina, ospemifene exerts an estrogen-like effect on the vaginal epithelium. The review focuses on data demonstrating the antiestrogenic activity of ospemifene in several unique breast cancer animal models, and the implications for utilizing ospemifene in patients with breast cancer suffering from VVA.
Department of Medicine T, Ichilov Hospital, Tel-Aviv, Israel
Wurz GT, Soe LH, Degregorio MW. Ospemifene, vulvovaginal atrophy, and breast cancer. Maturitas 2013 Jan 15. Epub ahead of print.
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