Looking at the cardiovascular system, it is clear that the heart has been extensively investigated and discussed in regard to the effects of menopause on the one hand, and hormone therapy (HT) on the other hand. But the area of peripheral arterial disease (PAD) in this respect has received much less attention. In a new cross-sectional study on 887 women aged 52–81 years, reproductive parameters were obtained by standardized interviews, and PAD was assessed by measuring non-invasively the ankle-brachial index (using a cut-off value of 0.9) and by assessing the presence of claudication using the Edinburgh questionnaire . The only significant associations with the presence of PAD were later age at menarche (> 15 years) compared to age at menarche between 12 and 15 years (odds ratio (OR) 0.48; 95% confidence interval (CI) 0.24–0.98), and the presence of hot flushes (OR 2.09; 95% CI 1.11–3.92). Other reproductive parameters, such as parity, age at menopause, time since menopause, duration of fertility, ever use or current use of HT, ever use of oral contraceptives, history of hysterectomy, bilateral oophorectomy and depressive mood in relation to menopausal transition showed no significant association with PAD.
Department of Medicine T, Ichilov Hospital, Tel-Aviv, Israel
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