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The potential association of postmenopausal hormone use and the occurrence of acute pancreatitis was investigated in a prospective study involving 31,494 postmenopausal women (aged 48–8  years) from the population-based Swedish Mammography Cohort [1]. Participants completed a baseline questionnaire in 1997 assessing their use of hormone replacement therapy (HRT). The cohort was linked to the hospital-based Swedish National Patient Register to determine hospital admissions for acute pancreatitis through 2010. Over a total follow-up of 389,456 person-years, 237 cases of incident acute pancreatitis were identified. The age-standardized incidence rates per 100,000 person-years were 71 cases among women who had ever used HRT and 52 cases among women who had never used such hormones. Among ever-users of HRT, the multivariable-adjusted relative risk (RR) of acute pancreatitis was 1.57 (95% confidence interval (CI) 1.20–2.05) compared with never-users. The risk did not differ by current or past use, but it seemed to be higher among women who used systemic therapy (RR = 1.92, 95% CI 1.38–2.66) and among those with duration of therapy of more than 10 years (RR = 1.87, 95% CI 1.11–3.17).

Author(s)

  • Amos Pines
    Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

Citations

  1. Oskarsson V, Orsini N, Sadr-Azodi O, Wolk A. Postmenopausal hormone replacement therapy and risk of acute pancreatitis: a prospective cohort study. CMAJ 2014 Jan 27. Epub ahead of print
    http://www.cmaj.ca/content/early/2014/01/27/cmaj.131064.full.pdf+html
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