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Since the timing of the onset of the last menstrual period in a woman’s life varies, less between cultures, but more individually, it has induced a universal challenge on how to predict the age at natural menopause (ANM). Fertility issues in women raise concerns for those who postpone their reproduction due to educational and professional goals. Anti-Müllerian hormone (AMH) seems to have a certain predictive role not only in ANM, ovarian reserve tests, premature ovarian insufficiency, assisted reproduction techniques but also in different clinical conditions such as polycystic ovary syndrome, ovarian surgery, granulosa cell tumors, cancer treatment, anorexia nervosa [1]. That is why the dynamics of AMH have been widely investigated by many groups; one of the intriguing issues is whether we can predict age at natural menopause using ovarian reserve tests or the mother’s age at menopause. Depmann and colleagues recently published a study and a review of the current literature [2, 3]. The review, which included six studies, was summarized as follows: ‘AMH is currently the most promising marker for ANM prediction. The predictive capacity of mother’s ANM demonstrated in a single study makes this marker a promising contributor to AMH for menopause prediction. Models, however, do not predict the extremes of menopause age very well and have a wide prediction interval. These markers clearly need improvement before they can be used for individual prediction of menopause in the clinical setting.’


  • Ivan Fistonić
    President of Institute for Women’s Health, Zagreb, Croatia; Professor at University of Applied Health Sciences, Zagreb, Croatia; Assistant Professor at University Department of Health Studies, University of Split, Split, Croatia


  1. Nelson SM. Biomarkers of ovarian response: current and future applications. Fertil Steril 2013;4:963-9
  2. Depmann M, Broer SL, van der Schouw YT, et al. Can we predict age at natural menopause using ovarian reserve tests or mother’s age at menopause? Menopause 2016;23:224-32
  3. Depmann M, Eijkemans MJ, Broer SL, et al. Does anti-Müllerian hormone predict menopause in the general population? Results of a prospective ongoing cohort study. Hum Reprod 2016;31:1579-87
  4. Dólleman M, Depmann M, Eijkemans MJ, et al. Anti-Mullerian hormone is a more accurate predictor of individual time to menopause than mother’s age at menopause. Hum Reprod 2014;29:584–91
  5. Richardson MC, Guo M, Fauser BC, Macklon NS. Environmental and developmental origins of ovarian reserve. Hum Reprod Update 2014;3:353-69
  6. Daan NM, Fauser BC. Menopause prediction and potential implications. Maturitas 2015;82:257–65
  7. Gohari MR, Ramezani Tehrani F, Chenouri S, Solaymani-Dodaran M, Azizi F. Individualized predictions of time to menopause using multiple measurements of antimüllerian hormone. Menopause 2016 Jun 20. Epub ahead of print
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