Recently, contradictory reports were published concerning the association between the serum concentration of irisin and the physical activity level and fitness status in healthy humans. Irisin is a newly identified myokine that induces the ‘browning’ of white adipose tissue (WAT). Buscemi and colleagues studied a cohort of 858 healthy individuals in Palermo, Sicily, as a part of the ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study, and found a significant positive correlation between serum irisin concentration and habitual physical activity . However, Binianinov and colleagues showed that serum irisin concentration was not related to any measures of short-term physical activity, habitual physical activity, or physical fitness in a cross-sectional analysis of 300 healthy humans who had participated in the Karlsruhe Metabolomics and Nutrition (KarMeN) study in Germany .
Department of Women’s Health, Tokyo Medical and Dental University, Tokyo, Japan
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