Hysterectomy with or without oophorectomy is a common procedure all over the world, mostly for benign conditions [1,2]. Notwithstanding, the long-term safety of hysterectomy alone has not been accurately evaluated. Studies addressing this issue have methodological flaws: not controlling for pre-existing cardiovascular disease, inclusion of unilateral oophorectomy in the ovarian conservation group, and short-term follow-up [3,4].
Laughlin-Tommaso and colleagues have studied a cohort of 2094 women in Olmsted County in the USA; the women underwent hysterectomy with ovarian conservation (both ovaries) for benign conditions between the years 1980 and 2002, and were matched with women who had not undergone this procedure . Indications for hysterectomy were mainly leiomyomas (39.5%), uterine prolapse (20.3%), and menstrual disorders not specifically defined (25.5%). They evaluated the incidence of de novo cardiovascular disease and associated metabolic conditions, by using electronic registry of the outcome for a median follow up of 21.9 years. The study found a significant correlation between the development of cardiometabolic disease and hysterectomy, in all age groups.
Resident Endocrinology Department, Faculty of Medicine, Pontificia Universidad Católica de Chile
Endocrinology Department, Pontificia Universidad Católica de Chile
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