Skip to content

A total of 2341 postmenopausal women were recruited in five centers in Italy during 2006 and 2007 for quantitative ultrasound (QUS) measurement at the phalanges during a screening program for osteoporosis [1]. Two ultrasound parameters were collected: amplitude-dependent speed of sound (AD-SoS) and ultrasound bone profile index (UBPI). Women were then re-contacted in 2010 ([i]n[/i] = 2211) and were asked about fracture occurrence during the period since previous QUS measurement. The mean age of the recruited women was 60.9 ± 10.0 years, the mean age at menopause was 49.3 ± 4.4 years, and the mean body mass index (BMI) was 26.5 ± 4.6 kg/m[+]2[/+]. A total number of 108 new major osteoporotic fractures occurred during the 3-year period, of which 23 were hip fractures and 51 were vertebral fractures. The relative risk (RR) per standard deviation (SD) decrease for major fractures was 1.77 (95% confidence interval (CI) 1.59–1.97) for AD-SoS and 2.06 (95% CI 1.78–2.37) for UBPI. When corrected for age, BMI, and age at menopause, the RRs were still significant and equal to 1.44 (95% CI 1.26–1.65) for AD-SoS and 1.67 (95% CI 1.39–2.00) for UBPI. The RR for vertebral fractures was 1.63 (95% CI 1.41–1.88) for AD-SoS and 1.73 (95% CI 1.44–2.08) for UBPI. The RR for hip fractures was 1.92 (95% CI 1.55–2.37) for AD-SoS and 2.68 (95% CI 1.86–3.86) for UBPI. Thus, this study showed that ultrasound parameters AD-SoS and UBPI were able to significantly predict future major fractures in a prospective cohort of more than 2000 postmenopausal women.

Author(s)

  • Amos Pines
    Department of Medicine T, Ichilov Hospital, Tel-Aviv, Israel

Citations

  1. Guglielmi G, Rossini M, Nicolosi MG, et al. Three-year prospective study on fracture risk in postmenopausal women by quantitative ultrasound at the phalanges. J Clin Densitom 2012 Aug 15. Epub ahead of print.
    http://www.ncbi.nlm.nih.gov/pubmed/22901551
  2. US Preventive Services Task Force. Screening for osteoporosis: US preventive services task force recommendation statement. Ann Intern Med 2011;154:356-64.
    http://www.ncbi.nlm.nih.gov/pubmed/21242341
  3. McCloskey E, Kanis JA. FRAX updates 2012. Curr Opin Rheumatol 2012;24:55460.
    http://www.ncbi.nlm.nih.gov/pubmed/22820516
  4. Moayyeri A, Adams JE, Adler RA, et al. Quantitative ultrasound of the heel and fracture risk assessment: an updated meta-analysis. Osteoporos Int 2012;23:143-53.
    http://www.ncbi.nlm.nih.gov/pubmed/22037972
  5. Chan MY, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria. Osteoporos Int 2012 Aug 10. Epub ahead of print.
    http://www.ncbi.nlm.nih.gov/pubmed/22878531
  6. Flater M, Bittar CK, Zabeu JL, Carneiro AC. Review of comparative studies between bone densitometry and quantitative ultrasound of the calcaneus in osteoporosis. Acta Reumatol Port 2011;36:327-35.
    http://www.ncbi.nlm.nih.gov/pubmed/22472924
  7. Albanese CV, Cepollaro C, de Terlizzi F, Brandi ML, Passariello R. Performance of five phalangeal QUS parameters in the evaluation of gonadal-status, age and vertebral fracture risk compared with DXA. Ultrasound Med Biol 2009;35:537-44.
    http://www.ncbi.nlm.nih.gov/pubmed/19097682
International Menopause Society

Install International Menopause Society - DEV

Install this application on your home screen for quick and easy access when you’re on the go.

Just tap then “Add to Home Screen”

DBS Check Online Certified